The Distribution, Metabolism, and Excretion of Hydrazine in Rat and Mouse.

نویسندگان

  • T DAMBRAUSKAS
  • H H CORNISH
چکیده

Prior to World War II, hydrazine was primarily of scientific interest without wide application for practical purposes. However, during World War II the Germans developed techniques for the production of hydrazine hydrate on a tonnage scale for use as rocket and jet fuel, and since then hydrazine and its derivatives have attracted increasing attention from chemists, manufacturers, and the military, Presently, the application of hydrazine and its derivatives include uses in research laboratories, production of fuel, explosives, photographic chemicals, chemiluminescent materials, insecticides, plastics, rubber chemicals, textile treating agents, dyes, pharmaceuticals, antioxidant preservatives, metallization of glass, solder flux for aluminum and magnesium alloys, and a variety of military applications. To a limited extent the toxicity of hydrazine has been studied and its toxic properties have been determined. However, the complete metabolic aspects of this compound are not defined. This paper presents a study of the tissue distribution, metabolic pattern, and excretion of hydrazine in the mouse and rat.

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عنوان ژورنال:
  • Toxicology and applied pharmacology

دوره 6  شماره 

صفحات  -

تاریخ انتشار 1964